Drug Reference

Urea

Solutions producing osmotic diuresis

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Fact box

Therapeutic class
Solutions producing osmotic diuresis
Habit forming
No
Availability
Prescription (Rx)

Brand names

AluveaAqua CareAquaphilic with UreaAtrac-TainCEM-UreaCarmolEpimide 50GormelGormel 10Hydrasyn25Hydro 35Hydro 40Kera NailKera-42KeralacNutraplusRea Lo 39Rea-LoU-KeraU-LactinUltra MideUmectaUramaxinUreacin-10Ureacin-20Utopic

Available as

100 MG/ML · Topical Cream50 MG/ML · Topical Cream390 MG/ML · Topical Cream60 MG/ML · Topical Cream410 MG/ML · Topical Cream420 MG/ML · Topical Cream0.47 MG/MG · Topical Gel470 MG/ML · Topical Cream30 MG/ML · Topical Cream375 MG/ML · Topical Cream400 MG/ML · Topical Cream100 MG/ML0.1 MG/MG · Topical Ointment200 MG/ML · Topical Cream0.2 MG/MG · Topical Ointment0.5 MG/MG300 MG/ML · Topical Cream425 MG/ML · Topical Cream250 MG/ML350 MG/ML · Topical Cream50 MG/ML20 MG/ML0.5 MG/MG · Topical Ointment0.05 MG/MG · Topical Ointment

FDA label sections are from openFDA and may not reflect the most recent labeling — confirm against the current DailyMed label.

Uses
Indications and Usage For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.
How it works
Clinical Pharmacology Urea gently dissolves the intercellular matrix which results in loosening the horny layer of skin and shedding scaly skin at regular intervals, thereby softening hyperkeratotic areas of the skin.
How to use / dosing
Dosage and Administration Apply Urea 40% to affected skin twice per day, or as directed by your physician. Rub in until completely absorbed. Apply to diseased or damaged nail(s) twice per day, or as directed by a physician.
Side effects
Adverse Reactions Transient stinging, burning, itching or irritation may occur and normally disappear upon discontinuing the use of this product. To report SUSPECTED ADVERSE REACTIONS, contact Method Pharmaceuticals, LLC at 1-877-250-3427; or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch .

Safety advice

Conservative summary derived from FDA labeling — defaults to “consult your doctor” unless the label is explicit. Not a substitute for your clinician’s advice.

PregnancyNo information
No specific information in the FDA label.
BreastfeedingNo information
No specific information in the FDA label. Check LactMed →
AlcoholNo information
No specific information in the FDA label.
DrivingNo information
No specific information in the FDA label.
KidneyNo information
No specific information in the FDA label.
LiverNo information
No specific information in the FDA label.
Warnings & precautions
Warnings For topical use only. Avoid contact with eyes, lips or mucous membranes.
Contraindications
Contraindications Known hypersensitivity to any of the listed ingredients.
Current FDA labels (DailyMed)

86 marketed products on record (RxNorm)

Authoritative sources

Reference only — not clinical advice. Verify against current FDA labeling and consult a licensed provider. About half of pediatric drug use is off-label and is not reflected in FDA labels; absence of pediatric information does not mean a medicine is unused or unsafe in children.