Drug Reference
Pyrilamine
Substituted ethylene diamines
OTC
Fact box
- Therapeutic class
- Substituted ethylene diamines
- Habit forming
- No
- Availability
- Over-the-counter (OTC)
Brand names
NinjacofNinjacof APamprin Multi-SymptomPediaclearPoly Hist PDPremsyn PMSVanacof AC
Available as
0.5 MG/ML · Nasal Spray500 MG · Oral Tablet600 MG0.0847 MG/MG2 MG/ML · Oral Solution2.5 MG/ML · Oral Solution325 MG · Oral Tablet0.4 MG/ML · Oral Suspension1.5 MG/ML · Oral Solution20 MG/ML32 MG/ML · Oral Solution25 MG · Oral Tablet0.417 MG/ML · Oral Solution1 MG/ML · Oral Solution12.5 MG · Oral Tablet30 MG · Oral Tablet20 MG/ML · Topical Cream0.833 MG/ML · Oral Solution1.6 MG/ML4 MG · Oral Tablet12.5 MG · Chewable Tablet3 MG/ML · Oral Solution6 MG/ML · Oral Solution60 MG · Oral Tablet
FDA label sections are from openFDA and may not reflect the most recent labeling — confirm against the current DailyMed label.
Uses
Uses for the temporary relief of these symptoms associated with menstrual periods: cramps bloating water-weight gain headache backache muscle aches fatigue
How to use / dosing
Directions do not exceed recommended dosage adults and children 12 years and over: take 2 caplets with water. Repeat every 6 hours as needed. Do not exceed 6 caplets per day. children under 12 years: consult a doctor
Safety advice
Conservative summary derived from FDA labeling — defaults to “consult your doctor” unless the label is explicit. Not a substitute for your clinician’s advice.
PregnancyConsult your doctor
…more than 10 days fever gets worse or lasts for more than 3 days If pregnant or breast-feeding ask a health professional before use.…
BreastfeedingConsult your doctor
…days fever gets worse or lasts for more than 3 days If pregnant or breast-feeding ask a health professional before use.…
AlcoholConsult your doctor
…for this product with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert Acetaminophen may cause severe skin or severe allergic reactions.…
DrivingConsult your doctor
…sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery limit the use of caffeine-containing medications, foods, or beverages because too much caffeine may cause nervousness, irritability sleeplessness,…
KidneyNo information
No specific information in the FDA label.
LiverConsult your doctor
…Warnings Liver warning: This product contains acetaminophen.…
Warnings & precautions
Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take: more than 6 caplets in 24 hours, which is the maximum daily amount for this product with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert Acetaminophen may cause severe skin or severe allergic reactions. Symptoms may include: • skin reddening blisters rash hives facial swelling asthma (wheezing) shock If a skin or general allergic reaction occurs, stop use and seek medical help right away. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen ask a doctor or pharmacist if you have ever had an allertgic reaction to this product or any of its ingredients Ask a doctor before use if you have liver disease glaucoma difficulty in urination due to enlargement of the prostate gland a breathing problem such as emphysema or chronic bronchitis Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product you may get drowsy avoid alcoholic drinks excitability may occur, especially in children alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery limit the use of caffeine-containing medications, foods, or beverages because too much caffeine may cause nervousness, irritability sleeplessness, and, occasionally rapid heartbeat. The recommended dose of this product contains about as much caffeine as a cup of coffee. Stop use and ask a doctor if new symptoms appear redness or swelling is present pain gets worse or lasts for more than 10 days fever gets worse or lasts for more than 3 days If pregnant or breast-feeding ask a health professional before use. Keep out of reach of chlidren. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Current FDA labels (DailyMed)
- ACETAMINOPHEN 500 PYRILAMINE MALEATE 15 AND CAFFEINE 60 (ACETAMINOPHEN 500MG PYRILAMINE MALEATE 15MG AND CAFFEINE 60MG TABLETS) TABLET, FILM COATED [HEALTH PHARMA USA LLC]
- MIDOL COMPLETE (ACETAMINOPHEN, CAFFEINE, AND PYRILAMINE MALEATE) TABLET [SELECT CONSUMER GROUP]
- MENSTRUAL COMPLETE (ACETAMINOPHEN, CAFFEINE, PYRILAMINE MALEATE) TABLET, FILM COATED [RITE AID CORPORATION]
- MENSTRUAL COMPLETE (ACETAMINOPHEN, CAFFEINE, PYRILAMINE MALEATE) TABLET, FILM COATED [MEIJER DISTRIBUTION, INC.]
- MENSTRUAL RELIEF MAXIMUM STRENGTH (ACETAMINOPHEN, PAMABROM, PYRILAMINE MALEATE) TABLET, FILM COATED [TOPCO ASSOCIATES, LLC]
Authoritative sources
Reference only — not clinical advice. Verify against current FDA labeling and consult a licensed provider. About half of pediatric drug use is off-label and is not reflected in FDA labels; absence of pediatric information does not mean a medicine is unused or unsafe in children.