Drug Reference
Doxylamine
Aminoalkyl ethers
OTC
Fact box
- Therapeutic class
- Aminoalkyl ethers
- Action class
- Antihistamine
- Mechanism
- Histamine Receptor Antagonists
- Habit forming
- No
- Availability
- Over-the-counter (OTC)
Brand names
Aldex ANBonjestaDiclegisNoctoUnisomWal-Som (doxylamine)Zzzquil Ultra
Available as
21.7 MG/ML · Oral Solution33.3 MG/ML · Oral Solution325 MG · Oral Capsule3 MG/ML · Oral Solution1.25 MG/ML · Oral Solution5 MG · Chewable Tablet25 MG · Oral Tablet1 MG/ML · Oral Solution1.5 MG/ML · Oral Solution250 MG · Oral Capsule250 MG · Oral Tablet10 MG · Oral Tablet7.5 MG · Oral Tablet650 MG · Powder500 MG · Oral Tablet325 MG · Oral Tablet20 MG · Extended Release Oral Tablet10.5 MG · Oral Tablet3.26 MG/ML · Oral Solution0.667 MG/ML · Oral Solution325 MG · Powder10 MG · Chewable Tablet15 MG · Chewable Tablet32.5 MG/ML · Oral Suspension
FDA label sections are from openFDA and may not reflect the most recent labeling — confirm against the current DailyMed label.
Uses
Use helps to reduce difficulty in falling asleep
How to use / dosing
Directions adults and children 12 years of age and over: take one tablet 30 minutes before going to bed; take once daily or as directed by a doctor children under 12 years of age: do not use
Safety advice
Conservative summary derived from FDA labeling — defaults to “consult your doctor” unless the label is explicit. Not a substitute for your clinician’s advice.
PregnancyConsult your doctor
…If pregnant or breast-feeding, ask a health professional before use.…
BreastfeedingConsult your doctor
…If pregnant or breast-feeding, ask a health professional before use.…
AlcoholCaution
…other antihistamines any other drugs When using this product avoid alcoholic beverages do not drive a motor vehicle or operate machinery take only at bedtime Stop use and ask a doctor if sleeplessness persists continuously for more than two weeks.…
DrivingCaution
…any other drugs When using this product avoid alcoholic beverages do not drive a motor vehicle or operate machinery take only at bedtime Stop use and ask a doctor if sleeplessness persists continuously for more than two weeks.…
KidneyNo information
No specific information in the FDA label.
LiverNo information
No specific information in the FDA label.
Warnings & precautions
Warnings Do not use in children under 12 years of age with any other product containing doxylamine unless you have time for a full night’s sleep Ask a doctor before use if you have a breathing problem such as emphysema or chronic bronchitis glaucoma trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are taking sedatives or any other sleep-aid tranquilizers any other antihistamines any other drugs When using this product avoid alcoholic beverages do not drive a motor vehicle or operate machinery take only at bedtime Stop use and ask a doctor if sleeplessness persists continuously for more than two weeks. Insomnia may be a symptom of serious underlying medical illness. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
Current FDA labels (DailyMed)
- NIGHTTIME SLEEP AID (DOXYLAMINE SUCCINATE) TABLET [H E B]
- NIGHTTIME COLD AND FLU (ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE) SOLUTION [CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED]
- NIGHTTIME SEVERE COLD AND FLU (ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HCL) SOLUTION [CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED]
- SLEEP-AID (DOXYLAMINE SUCCINATE) TABLET [CARDINAL HEALTH 110, LLC. DBA LEADER]
- NOCTO SLEEP AID (DOXYLAMINE SUCCINATE) TABLET [BELMORA LLC]
Authoritative sources
Reference only — not clinical advice. Verify against current FDA labeling and consult a licensed provider. About half of pediatric drug use is off-label and is not reflected in FDA labels; absence of pediatric information does not mean a medicine is unused or unsafe in children.